姜岷,男,1972年生,工學(xué)博士,教授,博士生導(dǎo)師,江蘇省第四期“333高層次人才培養(yǎng)工程”培養(yǎng)對象,江蘇省青藍(lán)工程骨干教師,南京工業(yè)大學(xué)生物與制藥工程學(xué)院副院長。江蘇省生物技術(shù)協(xié)會副秘書長,中德生物科技雙邊合作協(xié)調(diào)員,南京工業(yè)大學(xué)首批“工大俊才”高層次人才培養(yǎng)項目培養(yǎng)對象,優(yōu)秀黨務(wù)工作者,教書育人先進(jìn)個人
個人簡歷
1995. 7 南京化工大學(xué) 生物工程 學(xué)士
2000. 8 南京化工大學(xué) 化學(xué)工程 工學(xué)博士
2000. 9-2002. 8 韓國科學(xué)技術(shù)院 博士后
2002. 9-2004. 8 南京工業(yè)大學(xué) 講師
2004. 9-2008. 8 南京工業(yè)大學(xué) 副研究員 碩士生導(dǎo)師
2005.05-2008.09 南京工業(yè)大學(xué)生物與制藥工程學(xué)院 院長助理
2008. 9-2009.8 南京工業(yè)大學(xué) 研究員 碩士生導(dǎo)師
2009. 9-2011 南京工業(yè)大學(xué) 教授 碩士生導(dǎo)師
2011至今 南京工業(yè)大學(xué) 教授 博士生導(dǎo)師
2008.10至今 南京工業(yè)大學(xué)生物與制藥工程學(xué)院 副院長
研究領(lǐng)域
長期從事發(fā)酵工程、基因工程及代謝工程的工作,在生物合成聚羥基烷酸、聚谷氨酸、聚賴氨酸等生物高分子,丁二酸、富馬酸、蘋果酸、乳酸等有機(jī)酸以及氨基酸與酶生產(chǎn)中積累了豐富的理論與實踐經(jīng)驗,并且參與過多項擴(kuò)試及產(chǎn)業(yè)化研究項目,如生物合成對羥基-D-苯甘氨酸、L-苯丙氨酸、D-苯丙氨酸等,具有豐富的工程技術(shù)經(jīng)驗與項目管理經(jīng)驗。目前作為課題負(fù)責(zé)人承擔(dān)國家“973”課題1項、國家“863”重大項目1項(子課題負(fù)責(zé)人),國家自然科學(xué)基金1項、江蘇省國際合作項目1項、江蘇省高校自然科學(xué)研究重大項目1項、國家重點實驗室開放基金1項、德國EVONIC公司開發(fā)項目1 項。承擔(dān)完成國家自然科學(xué)基金1項、江蘇省科技成果轉(zhuǎn)化項目1項、江蘇省高校自然科學(xué)研究計劃1項、留學(xué)回國基金1項,作為課題副組長完成國家863目標(biāo)導(dǎo)向性課題1項、江蘇省高技術(shù)招標(biāo)項目1項,作為課題骨干參與完成國家973項目1項,以及參與完成多項國家自然科學(xué)基金項目及國家十五攻關(guān)課題研究工作。近年來發(fā)表科技文章100余篇,SCI收錄27篇,EI 10余篇,其中包括Appl Environ Microbiol,Process Biochem等國外權(quán)威期刊,申請國家發(fā)明專利50余項,授權(quán)7項。至今指導(dǎo)與協(xié)助指導(dǎo)碩士生40人,畢業(yè)20人,指導(dǎo)博士生6人,畢業(yè)3人。
目前正在開展的工作包括利用野生菌(產(chǎn)琥珀酸放線桿菌,米根霉)及基因工程菌(大腸桿菌和谷氨酸棒桿菌的改造)生產(chǎn)C4有機(jī)酸,美白化妝品添加劑α-熊果苷的生物合成,丁醇的生物合成等課題,內(nèi)容涉及利用分子生物學(xué)方法進(jìn)行菌株改造,多參數(shù)發(fā)酵調(diào)控,發(fā)酵模型的構(gòu)建,代謝分析以及后期的產(chǎn)物分離純化等。
近年來課題組承擔(dān)的部分科研項目:
項目名稱 |
項目符號 |
經(jīng)費(fèi)來源 |
起止時間 |
木質(zhì)纖維素資源高效生物降解轉(zhuǎn)化中的關(guān)鍵科學(xué)問題研究 |
2011CB707405 |
國家973項目 |
2011.1- 2015.12 |
生物質(zhì)碳資源高效利用的途徑解析 |
2009CB724701 |
國家973項目 |
2009.1- 2013.9 |
利用可再生資源固定CO2制備丁二酸的研究 |
2006AA02Z235 |
國家“863”重大項目 |
2006.12-2008.12 |
聚丁二酸丁二醇酯的生物-化學(xué)組合合成技術(shù) |
2011AA02A203 |
國家“863”重點項目 |
2011-2015 |
基于NAD(H)系統(tǒng)改造與調(diào)控的產(chǎn)丁二酸大腸桿菌代謝工程研究 |
21076105 |
國家自然科學(xué)基金 |
2011.1- 2013.12 |
應(yīng)用新型厭氧生物反應(yīng)裝置過程耦合合成丁二酸的研究 |
20606017 |
國家自然科學(xué)基金 |
2007.1- 2009.12 |
生物法固定二氧化碳合成丁二酸的研究 |
05KJB180043 |
省屬高校自然科學(xué)研究計劃項目 |
2005.7- 2007.12 |
利用玉米加工廢棄物制備PBS類生物可降解材料 |
BG2007001 |
江蘇省科技計劃項目 |
2007.4- 2010.4 |
生物法生產(chǎn)萬噸四碳系列食用有機(jī)酸 |
BA2009049 |
江蘇省科技成果轉(zhuǎn)化項目 |
2009.9- 2012.9 |
利用木質(zhì)纖維素制備燃料丁醇關(guān)鍵技術(shù)研究 |
|
江蘇高校自然科學(xué)基金重大項目 |
2011-2013 |
重組大腸桿菌生物合成丁二酸的產(chǎn)業(yè)化關(guān)鍵技術(shù)研究 |
|
江蘇省國際合作計劃項目 |
2011-2013 |
千噸丁二酸的產(chǎn)業(yè)化示范裝置 |
|
中石化科技開發(fā)項目 |
2011-2013 |
利用可再生資源制備C4二酸的研究 |
205093 |
橫向開發(fā)研究項目 |
2005.1- 2007.12 |
木質(zhì)纖維素發(fā)酵產(chǎn)丁醇的關(guān)鍵技術(shù)研究 |
201004001 |
其他來源 |
2011.1- 2013.12 |
近年來發(fā)表的部分SCI文章:
[1] Min Jiang*, Shuwen Liu, Jiangfeng Ma, Kequan Chen, Li Yu, Fangfang Yue, Ping Wei. Effect of Growth Phase Feeding Strategies on Succinate Production by Metabolically Engineered E. coli. Applied and Environmental Microbiology, 2010, 76(4): 1298-1300
[2] Min Jiang*, Kequan Chen, Zhongmin Liu, Ping Wei, Hanjie Ying, Honam Chang. Succinic Acid Production by Actinobacillus succinogenes Using Spent Brewer's Yeast Hydrolysate as a Nitrogen Source. Applied Biochemistry and Biotechnology, 2010, 160(1), 244-254
[3] Min Jiang, Longan Shang, Ping Wei, Ronghua Yu, Ning Shen, Pingkai Ouyang, Ho Nam Chang. Pilot-scale production of d-p-hydroxyphenylglycine from dl-5-p-hydroxyphenylhydantoin by Burkholderia cepacia JS-02 (2007). Enzyme and Microbial Technology, 41: 407–412
[4] KQ Chen, J Li, Ma JF, M Jiang*, P Wei, ZM Liu, HJ Ying. Succinic acid production by Actinobacillus succinogenes using hydrolysates of spent yeast cells and corn fiber. Bioresource Technology, 2011, 102: 1704-1708
[5] Kequan Chen, Min Jiang*, Ping Wei, Jiaming Yao and Hao Wu. Succinic Acid Production from Acid Hydrolysate of Corn Fiber by Actinobacillus succinogenes. Applied Biochemistry and Biotechnology, 2010, 160(2), 477-485
[6] Jian Li, Min Jiang*, Kequan Chen, Longan Shang, Ping Wei, Hanjie Ying, Qi Ye, Pingkai Ouyang,Honam Chang. Enhanced production of succinic acid by Actinobacillus succinogenes with reductive carbon source. Process Biochemistry, 2010, 45(6):980-985
[7] Jiang-Feng Ma, Min Jiang*, Ke-Quan Chen, Bing Xu, Shu-Wen Liu, Ping Wei, Han-Jie Ying. Succinic acid production with metabolically engineered E. coli recovered from two-stage fermentation. Biotech Lett. 2010, 32(10):1413-1418
[8] Jian Li, Min Jiang*, Ke-Quan Chen, Qi Ye, Long-An Shang, Ping Wei, Han-Jie Ying, Ho-Nam Chang. Effect of redox potential regulation on succinic acid production by Actinobacillus succinogenes. Bioprocess and Biosystems Engineering, 2010, 33(8):911-920
[9] KQ Chen, H Zhang, YL Miao, M Jiang*, JY Chen. Succinic acid production from enzymatic hydrolysate of sake lees using Actinobacillus succinogenes 130Z. Enzyme and Microbial Technology, 2010, 47:236-240
[10] RM Liu,LY Liang,KQ Chen,JF Ma,M Jiang*,P Wei,PK Ouyang. Fermentation of xylose to succininate by enhancement of ATP supply in metabolically engineered Escherichia coli. Applied Microbiology and Biotechnology, 2012, 94(4): 959-968
[11] J Li, XY Zheng, XJ Fang, SW L, KQ Chen, M Jiang*, P Wei, PK Ouyang. A complete industrial system for economical succinic acid production. Bioresource Technology, 102 (2011) 6147-6152
[12] JF Ma, M Jiang *, KQ Chen, B Xu, SW Liu, P Wei, HN Chang, PK Ouyang. Strategies for efficient repetitive production of succinate using metabolically engineered Escherichia coli. Bioprocess and Biosystems Engineering, 2011, 34(4):411-418
[13] LY Liang, RM Liu, JF Ma, KQ Chen, M Jiang*, P Wei. Increased production of succinic acid in Escherichia coli by overexpression of malate. Biotechnol Lett, 2011, 33(12):2439-2444
[14] YL Xi, KQ Chen, J Li, XJ Fang, XY Zheng, SS Sui, M Jiang*, P Wei. Optimization of culture conditions in CO2 fixation for succinic acid production using Actinobacillus succinogenes. J Ind Microbiol Biotechnol, 2011, 38(9):1605-1612
[15] T Guo, Y Tang, QY Zhang, TF Du, DF Liang, M Jiang*, PK Ouyang. Clostridium beijerinckii mutant with high inhibitor tolerance obtained by low-energy ion implantation. J Ind Microbiol Biotechnol, DOI 10.1007/s10529-011-0702-9
[16] XJ Fang, J Li, XY Zheng, YL Xi, KQ Chen, P Wei, PK Ouyang, M Jiang*. Enhancement of succinic acid production by osmotic-tolerant mutant strain of Actinobacillus succinogenes. World J Microbiol Biotechnol, 2011, 27(12):3009-3013
[17] XJ Fang, J Li, XY Zheng, YL Xi, KQ Chen, P Wei, PK Ouyang, M Jiang*. Influence of Osmotic Stress on Fermentative Production of Succinic Acid by Actinobacillus succinogenes. Applied Biochemistry and Biotechnology, 2011, 165(1): 138-147
[18] T Guo, Y Tang, YL Xi, AY He, BJ Sun, H Wu, DF Liang, M Jiang*, PK Ouyang. Clostridium beijerinckii mutant obtained by atmospheric pressure glow discharge producing high proportions of butanol and solvent yields. Biotechnol Lett, 2011, 33(12):2379–2383
[19] JX Xu, M Jiang*, HLSun, BF He. An organic solvent-stable protease from organic solvent-tolerant Bacillus cereus WQ9-2: Purification, biochemical properties, and potential application in peptide synthesis. Bioresource Technology, 2010, 101(20):7991-7994
[20] H Li, NJ Kim, M Jiang, JW Kang, HN Chang. Simultaneous saccharification and fermentation of lignocellulosic residues pretreated with phosphoric acid-acetone for bioethanol production. Bioresource Technology, 2009, 100(13): 3245-3251
[22] Gui-zi Ye, Min Jiang*, Jian Li, Ke-quan Chen, Yong-lan Xi, Shu-wen Liu, Ping Wei, and Ping-kai Ouyang. Isolation of NH4+-Tolerant Mutants of Actinobacillus succinogenes for Succinic Acid Production by Continuous Selection. J Microbiol Biotechnol, 2010, 20(8): 1219-1225
[23] Shang LG, Jiang M, Yun Z, Yan HQ , Chang HN. Mass production of medium-chain-length poly (3-hydroxyalkanoates) from hydrolyzed corn oil by fed-batch culture of Pseudomonas putida. World Journal of Microbiology and Biotechnology, 2008, 24(12): 2783-2787
[24] Longan Shang, Min Jiang, Chul Hee Ryu, Ho Nam Chang, Soon Haeng Cho, Jong Won Lee. Inhibitory Effect of Carbon Dioxide on the Fed-Batch Culture of Ralstonia eutropha: Evaluation by CO2 Pulse Injection and Autogenous CO2 Methods. Biotechnology and Bioengineering, 83(3): 312-320
[25] Longan Shang, Min Jiang, Ho Nam Chang. Poly (3-hydroxybutyrate) synthesis in fed-batch culture of Ralstonia eutropha with phosphate limitation under different glucose concentrations. Biotechnology Letters, 25(17): 1415-1419
[26] Longan Shang, Jin Hwan Do, Fan Daidi, Jiang Min, Honam Chang. Optimization of Propionic acid feeding for Production of Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) in Fed-Batch Culture of Ralstonia eutropha. Chinese J. Chem. Eng, 11(2): 220-223
聯(lián)系方式:
025-58139933 E-mail:jiangmin@njut.edu.cn