許德麟
博士、副研究員、碩士生導(dǎo)師、生態(tài)學(xué)系黨總支書記
――― 研究方向 ―――
主要從事微生物資源開發(fā)利用及水產(chǎn)養(yǎng)殖生態(tài)相關(guān)領(lǐng)域研究,具體方向包括水產(chǎn)益生菌開發(fā),水產(chǎn)病害生物防治技術(shù),微生態(tài)制劑研發(fā)與應(yīng)用等。研究成果主要服務(wù)于綠色生態(tài)養(yǎng)殖模式構(gòu)建、促進水產(chǎn)養(yǎng)殖業(yè)健康可持續(xù)發(fā)展,養(yǎng)殖水域生態(tài)環(huán)境保護等。
――― 主講課程 ―――
本科課程:微生物學(xué)、生態(tài)學(xué)分子方法技術(shù)及應(yīng)用、分子微生物學(xué)(全英)
研究生課程:生態(tài)學(xué)研究方法
――― 主要學(xué)習(xí)工作經(jīng)歷 ―――
2012.10 至今 暨南大學(xué)生命科學(xué)技術(shù)學(xué)院生態(tài)學(xué)系,副研究員(2014年起)
2010.12 - 2011.12 香港浸會大學(xué),博士后
2008.10 - 2010.10 法國巴黎第11大學(xué),博士后
2004.09 –2008.02 韓國明知大學(xué),生物學(xué)專業(yè),博士
2002.09 –2004.08 韓國明知大學(xué),環(huán)境工程與生物技術(shù)專業(yè),碩士
――― 主持的科研項目 ―――
1. 國家自然科學(xué)基金面上項目(32271568):鏈霉菌SH5腸道定植及群感效應(yīng)調(diào)節(jié)機制,2023.01 ~ 2026.12
2. 廣東省自然科學(xué)基金(2023A1515012806):鏈霉菌SH5防控嗜水氣單胞菌感染的益生作用機制,2023.01~2025.12
3. 國家自然科學(xué)基金重點項目子課題(42030713):微生物介導(dǎo)作物吸收累積新興有機污染物的環(huán)境生物地球化學(xué)機制,2021.01 ~ 2025.12
4. 廣州市科技計劃項目:基礎(chǔ)與應(yīng)用基礎(chǔ)研究(202102080372):潛在益生鏈霉菌株S073防治弧菌病機制的研究,2021.04~2023.03
5. 廣東省科技計劃項目(No. [2019]170):廣東特色水產(chǎn)品生態(tài)養(yǎng)殖技術(shù)集成與示范指導(dǎo)項目,2019.10~2021.10
6. 廣東省自然科學(xué)基金(2019A1515011791):鐵載體介導(dǎo)的海洋鏈霉菌S073防控弧菌病機制的研究,2019.10~2022.9
7. 廣東省自然科學(xué)基金(2018A030313578):乙酰轉(zhuǎn)移酶SCO0988調(diào)控鏈霉菌抗生素合成的機理,2018.10~2021.10
8. 廣東省自然科學(xué)基金(2015A030313319):弧菌特異性抑制劑的篩選及防治弧菌病效果的研究,2015.10~2018.10
9. 國家自然科學(xué)基金青年(31300046):TetR家族蛋白,SCO3201,在天藍色鏈霉菌和變鉛青鏈霉菌中下游調(diào)控靶基因的鑒定及功能分析,2014.01 ~ 2016.12
10. 廣東省自然科學(xué)基金(S2013010013705):鏈霉菌中對一TetR家族轉(zhuǎn)錄調(diào)控因子調(diào)控目標(biāo)基因的鑒定,2013.10 ~ 2015.10
11. 農(nóng)業(yè)部南海漁業(yè)資源開發(fā)利用重點實驗室開放基金(LSF2013-07):水霉拮抗放線菌的篩選及預(yù)防水霉感染效果研究,2013.08 ~ 2015.07
――― 發(fā)表的論文 ―――
1. Qiting Liang†, Ganxing Liu†, Zheng Guo†, Yuting Wang, Zhongheng Xu, Yuxian Ren, Qizhong Zhang*, Miao Cui*, Xinqing Zhao*, Delin Xu* (2022) Application of potential probiotic strain Streptomyces sp. SH5 on anti-Aeromonas infection in zebrafish larvae. Fish and Shellfish Immunology. 127: 375–385
2. Miao Cui*, Zibin Wang, Yongchun Yang, Ru Liu, Min Wu, Yujie Li, Qizhong Zhang and Delin Xu* (2022) Comparative Transcriptomic Analysis Reveals the Regulated Expression Profiles in Oreochromis niloticus in Response to Coinfection of Streptococcus agalactiae and Streptococcus iniae. Frontiers in Genetics. doi: 10.3389/fgene.2022.782957
3. Yunwen Bi, Ganxing Liu, Qiushi Yu, Qiting Liang, Zhongheng Xu, Miao Cui*, Qizhong Zhang*, Delin Xu*(2021)Anti-Vibrio dibutyl phthalate from marine-derived Streptomyces sp. S073. Research in Veterinary Science. 140: 198-202
4. Tinglong Hou†, Delin Xu†, Miao Cui, Huiru Liu, Yaowu Fu, Lingli Zhang, Lei Tang, Yanmeng Liu, Qizhong Zhang* (2020) The transcriptional factor GATA-4 negatively regulates Hsp70 transcription in Crassostrea hongkongensis. Molecular Biology Reports. 47:7107–7114. DOI: 10.1007/s11033-020-05778-9
5. Jun Zhang†, Qiting Liang†, Zhongheng Xu, Miao Cui, Qizhong Zhang1, Sonia Abreu, Michelle David, Clara Lejeune, Pierre Chaminade, Marie-Joelle Virolle, Delin Xu* (2020) The inhibition of antibiotic production in Streptomyces coelicolor over-expressing the TetR regulator SCO3201 is correlated with changes in the lipidome of the strain. Frontiers in Microbiology. doi: 10.3389/fmicb.2020.01399
6. Luoqiang Zhang†, Delin Xu†, Feifei Wang, Qizhong Zhang (2019) Antifungal activity of Burkholderia sp. HD05 against Saprolegnia sp. by 2-pyrrolidone-5-carboxylic acid. Aquaculture. 511:634198
7. Miao Cui, Huijie Zhang, Jingjing Li, Ru Liu, Min Wu, Delin Xu*, Qizhong Zhang* (2019) Differential PCR detection of Streptococcus agalactiae and Streptococcus iniae in tilapia (Oreochromis niloticus) by a single primer pair. Journal of Fish Diseases. 42(8):1211-1216.
8. Mingxia Yang, Jun Zhang, Qiting Liang, Guanxin Pan, Jiachang Zhao, Miao Cui, Xinqing Zhao, Qizhong Zhang, Delin Xu* (2019) Antagonistic activity of marine Streptomyces sp. S073 on pathogenic Vibrio parahaemolyticus. Fisheries Science. 85:533–543
9. Delin Xu†, Di Wang†, Miao Cui, Qizhong Zhang* (2018) The purine-rich element-binding protein ChPur-α negatively regulates Hsc70 transcription in Crassostrea hongkongensis. Cell Stress and Chaperones. 23: 91-100
10. Huiru Liu†, Delin Xu†, Miao Cui, Tinglong Hou, Qizhong Zhang (2018)The transcriptional factor YB-1 positively regulates Hsc70 transcription in Crassostrea hongkongensis. Biochemical and Biophysical Research Communications. 495: 2404-2409
11. Lingli Zhang, Delin Xu, Miao Cui, Lei Tang, Tinglong Hou, Qizhong Zhang (2018) The guanine nucleotide-binding protein α subunit protein ChGnaq positively regulates Hsc70 transcription in Crassostrea hongkongensis. Biochemical and Biophysical Research Communications. 499: 215-220
12. Delin Xu†, Qin Yang†, Miao Cui and Qizhong Zhang (2017) The novel transcriptional factor HP1BP3 negatively regulates Hsp70 transcription in Crassostrea hongkongensis. Scientific Reports. | 7: 1401 | DOI:10.1038/s41598-017-01573-y
13. Lan Yan, Qizhong Zhang, Marie-Joelle Virolle, Delin Xu* (2017) In conditions of over-expression, WblI, a WhiB-like transcriptional regulator, has a positive impact on the weak antibiotic production of Streptomyces lividans TK24. PLoS One. https://doi.org/10.1371/journal.pone.0174781
14. Zongyu Miao†, Delin Xu†, Miao Cui, Qizhong Zhang (2016) High mobility group protein DSP1 negatively regulates HSP70 transcription in Crassostrea hongkongensis. Biochemical and Biophysical Research Communications. 474: 634-639
15. Delin Xu, Miao Cui and Qizhong Zhang (2016) Transcriptional Activity of Full-Length and Truncated Metallothionein Promoters of Crassostrea hongkongensis in Response to Metal Stress. Journal of Shellfish Research. 35(1): 83-89
16. Delin Xu†, Bo Yu, Yan Zhang, Miao Cui and Qizhong Zhang (2015) Metallothionein Protein Expression of Crassostrea hongkongensis in Response to Cadmium Stress. Journal of Shellfish Research. 34(2):311-318
17. Delin Xu†, Paul Waack, Qizhong Zhang, Sebastiaan Werten, Winfried Hinrichs, Marie-Joelle Virolle (2014) Structure and regulatory targets of SCO3201, a highly promiscuous TetR-like regulator of Streptomyces coelicolor M145. Biochem Biophys Res Commun. 450 : 513–518.
18. Ammaiyappan Selvam, Delin Xu, Zhenyong Zhao, Jonathan W.C. Won (2012) Fate of tetracycline, sulfonamide and fluoroquinolone resistance genes and the changes in bacterial diversity during composting of swine manure. Bioresource Technology. 126: 383-390
19. Delin Xu†, Nicolas Seghezzi†, Catherine Esnault and Marie-Joelle Virolle (2010) Repression of antibiotic production and sporulation in Streptomyces coelicolor by overexpression of a TetR family transcriptional regulator. Appl. Environ. Microbiol.76 (23): 7741-53
20. Delin Xu†, Tae-Jong Kim†, ZY Park, SK Lee, SH Yang, Hyung-Jin Kwon and Joo-Won Suh (2009) A DNA-binding factor, ArfA, interacts with the bldH promoter and affects undecylprodigiosin production in Streptomyces lividans. Biochem Biophys Res Commun. 379: 319-23
21. Delin Xu, Hyung-Jin Kwon and Joo-Won Suh (2008) S-Adenosylmethionine induces BldH and activates secondary metabolism by involving the TTA-codon control of bldH expression in Streptomyces lividans. Arch Microbiol. 189: 419-26
22. Su-Kyoung Shin†, Delin Xu†, Hyung-Jin Kwon & Joo-Won Suh (2006) S-Adenosylmethionine activates adpA transcription and promotes streptomycin biosynthesis in Streptomyces griseus. FEMS Microbio Lett 259: 53-59
――― 學(xué)術(shù)與社會兼職 ―――
國家自然科學(xué)基金、廣東省自然科學(xué)基金以及教育部學(xué)位論文評審人。Aquaculture、Frontiers in Microbiology、Journal of Fish Disease等學(xué)術(shù)期刊審稿人,Frontiers in Environmental Sciences期刊編委。廣東省/企業(yè)農(nóng)村科技特派員,廣州市農(nóng)村科技特派員,廣東省休閑漁業(yè)與垂釣協(xié)會智庫專家。
――― 榮譽與獎勵 ―――
1. 2021年“第十屆暨南大學(xué)教育教學(xué)成果獎”二等獎(第一完成人)
2. 2021年“第十屆暨南大學(xué)教育教學(xué)成果獎”一等獎(第七完成人)
3. “2020全國大學(xué)生生命科學(xué)創(chuàng)新創(chuàng)業(yè)大賽”一等獎,指導(dǎo)教師
4. “2018全國大學(xué)生生命科學(xué)創(chuàng)新創(chuàng)業(yè)大賽”三等獎,指導(dǎo)教師
5. 2020年度省級大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計劃項目(海洋鏈霉菌SH5所產(chǎn)活性蛋白防控弧菌病效果與機制研究),指導(dǎo)教師
6. 2019年度國家級大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計劃項目(海洋鏈霉菌防控弧菌病效果與機制的研究),指導(dǎo)教師
7. 暨南大學(xué)生命科學(xué)技術(shù)學(xué)院2019年度“本科教學(xué)突出個人貢獻獎”
8. 暨南大學(xué)本科教學(xué)校長獎(2015)
9. 暨南大學(xué)本科教學(xué)校長獎(2014)
10. “暨南大學(xué)第八屆本科課程教學(xué)競賽”三等獎(2019)
11. “暨南大學(xué)第六屆本科課程教學(xué)競賽”三等獎(2016)
12. “暨南大學(xué)第六屆本科課程全英語教學(xué)競賽”二等獎(2015)
13. “暨南大學(xué)首屆新任教師本科教學(xué)競賽”二等獎(2013)
14. 生命科學(xué)技術(shù)學(xué)院2019年度“優(yōu)秀班主任”
15. 主講/負責(zé)的“生物資源與利用”、“生態(tài)學(xué)專業(yè)英語”、“專業(yè)創(chuàng)新能力訓(xùn)練”課程先后在本科課程教學(xué)質(zhì)量評估排名結(jié)果中列入學(xué)院前10 %